sFRP3 inhibition improves age-related cellular changes in BubR1 progeroid mice
نویسندگان
چکیده
منابع مشابه
p21 both attenuates and drives senescence and aging in BubR1 progeroid mice.
BubR1 insufficiency occurs with natural aging and induces progeroid phenotypes in both mice and children with mosaic variegated aneuploidy syndrome. In response to BubR1 insufficiency, skeletal muscle, fat, and lens tissue engage p19(Arf) to attenuate senescence and age-related deterioration. Here, we address how p19(Arf) exerts this caretaker role using BubR1 progeroid mice lacking p53 or its ...
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ژورنال
عنوان ژورنال: Aging Cell
سال: 2019
ISSN: 1474-9718
DOI: 10.1111/acel.12899